Synthesis of 5,6-Dialkyl-4-aryl-2-aminopyridine-3-carbonitriles and In Vitro Study of Their Antimicrobial Activity
A three-component reaction for the synthesis of highly functionalized pyridine derivatives was studied. The cyclization reaction patterns were investigated, and it was shown that in the case of using methyl ethyl ketone and methyl isobutyl ketone, the methylene group participates in the condensation reaction. The biological activity of the obtained compounds against the Staphylococcus aureus and Pseudomonas aeruginosa bacteria, as well as Candida utilis yeast-like fungi was studied, and compounds with high antibacterial activity were revealed.
Authors
- Ekaterina Chernova (ORCID: https://orcid.org/0000-0002-2135-4540)
- D. M. Egorov (ORCID: https://orcid.org/0000-0003-3744-9306)
- И. Л. Кузикова (ORCID: https://orcid.org/0000-0001-6199-3104)
- Z. А. Zhakovskaya (ORCID: https://orcid.org/0000-0002-5620-1317)
- A. S. Krylov (ORCID: https://orcid.org/0000-0003-1773-7802)
- D. S. Bespalov
Institutions
- Russian Academy of Sciences (RU)
- State Research Center of the Russian Federation (RU)
- St. Petersburg State Technological Institute (RU)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1134/s1070363224120065
- Citations
- 6
- Primary Topic
- Multicomponent Synthesis of Heterocycles
- Type
- article
- Field-Weighted Citation Impact
- 1.50