Genetic diversity of Plasmodium falciparum reticulocyte binding protein homologue-5, which is a potential malaria vaccine candidate: baseline data from areas of varying malaria endemicity in Mainland Tanzania
Low levels of polymorphism in the pfrh5 gene were observed based on low nucleotide and haplotype diversity, a lack of population structure and negative Tajima's D values. This study provides essential data on the diversity of the Pfrh5 gene indicating that it can be considered in the development of the next generation malaria vaccines. Robust and intensive studies of this and other candidate genes are crucial to support the prioritization of the Pfrh5 gene for potential inclusion in a broadly cross-protective malaria vaccine.
Authors
- Sijenunu Aaron (ORCID: https://orcid.org/0009-0008-0793-3782)
- Ntuli Kapologwe (ORCID: https://orcid.org/0000-0003-0900-2937)
- Rashid A. Madebe
- Samwel Lazaro
- Abdallah Lusasi
- Beatus M. Lyimo
- Misago D. Seth (ORCID: https://orcid.org/0000-0002-6743-4108)
- Ruth B. Mbwambo (ORCID: https://orcid.org/0000-0002-1089-1236)
- Daniel Mbwambo (ORCID: https://orcid.org/0009-0001-1089-2482)
- Dativa Pereus (ORCID: https://orcid.org/0000-0003-2813-1312)
- Daniel P. Challe (ORCID: https://orcid.org/0000-0002-6009-4649)
- Deus S. Ishengoma (ORCID: https://orcid.org/0000-0003-2040-3416)
- Rule Budodo (ORCID: https://orcid.org/0000-0003-0297-9219)
- Catherine Bakari (ORCID: https://orcid.org/0000-0002-8710-1765)
- Celine I. Mandara (ORCID: https://orcid.org/0000-0003-4317-4425)
- Stella Kajange
- Salehe S. Mandai (ORCID: https://orcid.org/0009-0001-8088-8761)
- Ramadhan Moshi
- Daniel A. Petro
- Angelina J. Kisambale (ORCID: https://orcid.org/0009-0002-6913-6558)
- Gervas A. Chacha
Institutions
- Muhimbili University of Health and Allied Sciences (TZ)
- University of Dar es Salaam (TZ)
- African Malaria Network Trust (TZ)
- Kampala International University in Tanzania (TZ)
- Ministry of Health, Community Development, Gender, Elderly and Children (TZ)
- National Institute for Medical Research (TZ)
- Nelson Mandela African Institution of Science and Technology (TZ)
Publication Details
- Journal
- Malaria Journal
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s12936-025-05269-x
- Citations
- 4
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 7.51
Funders
- Bill and Melinda Gates Foundation