The Effect of Disulfiram and N-Acetylcysteine, Potential Compensators for Sulfur Disorders, on Lipopolysaccharide-Induced Neuroinflammation Leading to Memory Impairment and the Metabolism of L-Cysteine Disturbance
Our study did not confirm the suggested potential of DSF and NAC to correct memory disorders; however, it corroborated the notion that they reduced oxidative stress induced by LPS by increasing the NPSH level. Additionally, our study showed an increase in sulfate concentration in the brain tissues after LPS treatment, which means the upregulation of sulfite and sulfate production in inflammatory conditions.
Authors
- Małgorzata Iciek (ORCID: https://orcid.org/0000-0002-0422-0428)
- Giorgia Pia Lombardo
- Małgorzata Zygmunt (ORCID: https://orcid.org/0000-0003-2046-4155)
- Magdalena Kotańska (ORCID: https://orcid.org/0000-0002-3946-1192)
- Anna Bilska‐Wilkosz (ORCID: https://orcid.org/0000-0001-9066-6292)
- Marek Bednarski (ORCID: https://orcid.org/0000-0002-4639-9913)
- Anthea Miller
- Magdalena Górny (ORCID: https://orcid.org/0000-0002-6393-9977)
- Noemi Nicosia (ORCID: https://orcid.org/0000-0002-9453-1237)
- Paula Zammit
Institutions
- University of Messina (IT)
- Jagiellonian University (PL)
- University of Malta (MT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Molecules
- Published
- 2025-01-27
- DOI
- https://doi.org/10.3390/molecules30030578
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Jagielloński Collegium Medicum