Fly Ash:Sulfated Bi2O3-catalyzed Synthesis of Bioactive Arylimines and Arylamines

Series of arylimines and arylamines were synthesized by the fly ash:sulfated Bi2O3-catalyzed condensations of amines and aldehydes or 3-aminocarbazole and aryl enones under MW irradiation in solvent-free conditions in yields of higher than 60%. The synthesized compounds were characterized by their physical constants and spectroscopic data. The XRD structure of one of the synthesized imines, specifically (E)-N-(2,5-dimethoxybenzylidene)-2-phenoxyaniline imine was obtained. A molecular docking study of the synthesized arylimines and arylamines was performed, and their antimicrobial and antimalarial activities were assessed.