Substituted Ureas and Their Analogs Containing Framework Fragments: I. 1-(4-Hydroxyadamantan-1-yl)-3-(fluoro/chlorophenyl)ureas
Abstract A series of 1,3-disubstituted ureas containing a 4-(hydroxyadamantan-1-yl)-fragment were synthesized in yields of 55–87% by the reaction of 1-(4-oxoadamantan-1-yl)-3-(halophenyl)ureas with sodium borohydride . The synthesized ureas are potential metabolites and promising soluble human epoxide hydrolase inhibitors.
Authors
- V. S. D’yachenko (ORCID: https://orcid.org/0000-0002-6209-7106)
- E. K. Degtyarenko
- D. M. Zapravdina (ORCID: https://orcid.org/0000-0002-8654-2382)
- Д. В. Данилов (ORCID: https://orcid.org/0000-0001-8734-2617)
- В. В. Бурмистров (ORCID: https://orcid.org/0000-0002-8547-9166)
- E. S. Ilyina (ORCID: https://orcid.org/0009-0005-0475-1113)
Institutions
- Volgograd State Technical University (RU)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1134/s1070428024110034
- Citations
- 1
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- MIREA - Russian Technological University
- Russian Science Foundation