Synthesis of Functionalized Spiro[1-benzofuran-2,5'-pyrimidine] Derivatives of 5-Arylidenebarbituric Acids

Abstract Adducts of dimedone and 5-arylidenebarbituric acids react with N -bromosuccinimide in aqueous ethanol to give functionalized spiro[1-benzofuran-2,5'-pyrimidine] derivatives with moderate yields. The reaction of 5-benzylidenebarbituric acid with ethyl acetoacetate in the presence of N -bromosuccinimide provides spiro[pyrimidine-5,6'-furo[2,3- d ]pyrimidine].