Dahuang chuanxiong decoction against contrast-induced nephropathy: Multi-omics, crosstalk between BNIP3-mediated mitophagy and IL-17 pathway
In conclusion, these findings suggested that DCH may exert ameliorative effects on CI-AKI through a multifaceted approach, including inhibition of BNIP3-mediated mitophagy and IL-17-mediated inflammation. This study elucidated the renoprotective mechanism of DCH through transcriptomics, proteomics, and experimental validation, providing evidence for the therapeutic potential of this agent in the clinical treatment of CI-AKI.
Authors
- Xuezhong Gong (ORCID: https://orcid.org/0000-0002-4496-7972)
- Zhiyong Song (ORCID: https://orcid.org/0000-0002-2552-5239)
- Jun Li (ORCID: https://orcid.org/0000-0003-1945-1584)
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.phymed.2025.156416
- Citations
- 11
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 15.74
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality