Synthesis and Analgesic Activity of Substituted N-Alkyl-4-aryl-2-aroylhydrazylidene-4-oxobutanamides
A series of new substituted derivatives of N-alkyl-4-aryl-2-aroylhydrazylidene-4-oxobutanamides were synthesized via the opening of the furan ring in substituted 3-N-5-aryl-2-oxofuran-3(2H)-ylidene-4-R1-benzohydrazides under the action of various alkylamines. The in vivo analgesic activity and acute toxicity of the synthesized compounds were assessed to show that they have a pronounced analgesic activity and are almost nontoxic.
Authors
- I. N. Chernov (ORCID: https://orcid.org/0000-0002-0401-4405)
- Е. С. Денисламова (ORCID: https://orcid.org/0000-0003-1220-3625)
- E. I. Denisova (ORCID: https://orcid.org/0000-0002-9721-7200)
- D. V. Lipin (ORCID: https://orcid.org/0000-0003-2746-1395)
- D. A. Shipilovskikh (ORCID: https://orcid.org/0000-0001-6086-4300)
- Р. Р. Махмудов (ORCID: https://orcid.org/0000-0002-2326-3976)
- Н. М. Игидов (ORCID: https://orcid.org/0000-0003-0976-9951)
- O. V. Zvereva
Institutions
- ITMO University (RU)
- Perm National Research Polytechnic University (RU)
- Ministry of Health of the Russian Federation (RU)
- Solikamsk State Pedagogical Institute (RU)
- Perm State Pharmaceutical Academy (RU)
- N. I. Lobachevsky State University of Nizhny Novgorod (RU)
- Yaroslav-the-Wise Novgorod State University (RU)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2024-11-01
- DOI
- https://doi.org/10.1134/s1070428024110101
- Primary Topic
- Chemical synthesis and pharmacological studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00