An <scp>MRI</scp> assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis
Lesion expansion and shrinkage are affected by venous and WM tract factors, but these do not influence bexarotene's capacity to promote remyelination. This, instead, appears to be affected by surface-in factors. To limit lesion expansion and maximize tissue repair, multiple processes may need to be targeted.
Authors
- J William L Brown (ORCID: https://orcid.org/0000-0002-7737-5834)
- Amy Jolly (ORCID: https://orcid.org/0000-0002-7413-9772)
- Nick Cunniffe (ORCID: https://orcid.org/0000-0002-7562-2838)
- Alasdair Coles (ORCID: https://orcid.org/0000-0003-4738-0760)
- Ferrán Prados (ORCID: https://orcid.org/0000-0002-7872-0142)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Ermelinda De Meo (ORCID: https://orcid.org/0000-0001-5531-1111)
- Baris Kanber (ORCID: https://orcid.org/0000-0003-2443-8800)
- Rebecca S. Samson (ORCID: https://orcid.org/0000-0002-0197-702X)
- Declan Chard (ORCID: https://orcid.org/0000-0003-3076-2682)
Institutions
- Universitat Oberta de Catalunya (ES)
- Queen Mary University of London (GB)
- University of Cambridge (GB)
- National Institute for Health and Care Research (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- University College London (GB)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/acn3.52308
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- University of Cambridge
- University College London Hospitals NHS Foundation Trust
- NIHR Cambridge Biomedical Research Centre