Polymicrogyria in infants with symptomatic congenital cytomegalovirus at birth is associated with epilepsy: A retrospective, descriptive cohort study
The strongest correlate of epilepsy development was PMG. Infants with symptomatic cCMV at birth and PMG were more likely to develop epilepsy, and were likely to require one or more antiseizure medications. Parents of infants with cCMV and cortical malformations should be counselled regarding this risk. Including PMG severity in cCMV MRI scoring could improve epilepsy risk prediction.
Authors
- George Lawson (ORCID: https://orcid.org/0000-0001-5968-0010)
- Alexander Sheeka (ORCID: https://orcid.org/0000-0002-2176-0661)
- Pritika Gaur (ORCID: https://orcid.org/0000-0002-6286-9655)
- Nigel Basheer
- Hermione Lyall (ORCID: https://orcid.org/0000-0002-1255-1833)
- Wajanat Jan (ORCID: https://orcid.org/0000-0002-8803-7080)
- Carolina Kachramanoglou (ORCID: https://orcid.org/0000-0002-7874-0944)
- Styliani Alifieraki
Institutions
- Imperial College Healthcare NHS Trust (GB)
- Great Ormond Street Hospital (GB)
- Hammersmith Hospital (GB)
- University College London (GB)
- Imperial College London (GB)
Publication Details
- Journal
- Developmental Medicine & Child Neurology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1111/dmcn.16250
- Citations
- 1
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 1.35