Remote neurodegeneration in the lumbosacral cord one month after spinal cord injury: a cross‐sectional <scp>MRI</scp> study
One month after SCI, first signs of WM degeneration were apparent, without indication of tissue loss. The more pronounced differences observed in the lateral column could be attributed to anterograde degeneration of the motor tracts. The variability among DTI measurements remote from the lesion site can be partially explained by the degree of the SCI-induced neurological impairment. Together with previous studies, our findings indicate that impaired tissue integrity precedes tissue loss. The presented techniques have potential applications in monitoring the progression of various neurological diseases.
Authors
- Raphael Röthlisberger (ORCID: https://orcid.org/0000-0002-3685-3203)
- Lorenz Leitner (ORCID: https://orcid.org/0000-0001-5764-3494)
- Stephanie A. Stalder (ORCID: https://orcid.org/0000-0002-7914-8264)
- Patrick Freund (ORCID: https://orcid.org/0000-0002-4851-2246)
- Silvan Büeler (ORCID: https://orcid.org/0000-0003-3758-2043)
- Collene E. Anderson (ORCID: https://orcid.org/0000-0002-4350-6816)
- Gergely Dávid (ORCID: https://orcid.org/0000-0002-9379-5193)
- Veronika Birkhäuser (ORCID: https://orcid.org/0000-0002-6646-7266)
- Carl Moritz Zipser (ORCID: https://orcid.org/0000-0002-4396-4796)
- Nomah Mahnoor (ORCID: https://orcid.org/0009-0003-0109-4686)
- Ulrich Mehnert (ORCID: https://orcid.org/0000-0001-7963-8477)
- Oliver Gross (ORCID: https://orcid.org/0000-0002-3330-5623)
- Thomas M. Kessler (ORCID: https://orcid.org/0000-0002-1991-5919)
- Stéphanie van der Lely (ORCID: https://orcid.org/0000-0002-2688-9042)
- Christian W. Kündig (ORCID: https://orcid.org/0009-0007-0351-6108)
- Martina D. Liechti (ORCID: https://orcid.org/0000-0002-3024-0975)
Institutions
- University of Lucerne (CH)
- University of Zurich (CH)
- Universitätsklinik Balgrist (CH)
- Swiss Paraplegic Research (CH)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/acn3.52298
- Citations
- 1
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung