pH-Sensitive Amphiphilic Block Copolymer for Kaempferol Delivery in Controlled Drug Release Therapy for Chronic Obstructive Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a common pulmonary disorder with high morbidity, often leading to complications like pulmonary hypertension. Kaempferol, with its antioxidant and anti-inflammatory properties, shows promise in improving COPD outcomes. In this study, we developed a pH-sensitive fluorescent polymer, PAAS-DIA-SDOO, to load 4-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylic acid methyl ester and kaempferol, forming the nanocomposite PAAS-DIA-SDOO@1@Kaempferol. This nanocomposite demonstrated high drug-loading capacity and allowed real-time monitoring of drug release. In COPD model cells, it significantly enhanced cell proliferation and reduced inflammation, highlighting its potential as a smart drug delivery system for targeted COPD treatment. This innovation offers promising therapeutic improvements by enhancing drug efficacy and reducing side effects.