Exposure to Rifampicin and its Metabolite 25-Deacetylrifampicin Rapidly Decreases During Tuberculosis Therapy
Exposure to both RIF and 25-dRIF rapidly decreased during tuberculosis therapy. The contribution of 25-dRIF to overall drug exposure was low. Attainment of the target area under the concentration-time curve over 24 hours/minimum inhibitory concentration for RIF was poor, supporting an increased RIF dosage as an option to compensate for auto-induction.
Authors
- Charlotte Genestet (ORCID: https://orcid.org/0000-0001-6846-4053)
- Tristan Ferry (ORCID: https://orcid.org/0000-0003-3082-7001)
- François Parant (ORCID: https://orcid.org/0000-0002-4019-532X)
- Clément Javaux
- Paul Chabert (ORCID: https://orcid.org/0000-0001-8697-6415)
- Sandrine Roux
- Olivier Bahuaud (ORCID: https://orcid.org/0000-0002-1015-6987)
- Oana Dumitrescu (ORCID: https://orcid.org/0000-0001-8193-1437)
- Carole Chedid (ORCID: https://orcid.org/0000-0002-4488-0770)
- Aurélien Millet
- Rim Bayaa
- Maxime Simon (ORCID: https://orcid.org/0000-0002-2069-026X)
- Jonathan Hoffmann
- Elisabeth Hodille (ORCID: https://orcid.org/0000-0002-5144-1987)
- Florence Ader (ORCID: https://orcid.org/0000-0002-4778-4338)
- Evelyne Braun
- Gérard Lina (ORCID: https://orcid.org/0000-0002-9236-7998)
- Agathe Becker (ORCID: https://orcid.org/0000-0002-3013-0952)
- Sylvain Goutelle (ORCID: https://orcid.org/0000-0002-1853-2932)
- Pierre Chauvelot (ORCID: https://orcid.org/0000-0001-5486-3256)
- Anne Conrad
- Florent Valour (ORCID: https://orcid.org/0000-0002-1467-6162)
- T. Perpoint
- Cécile Pouderoux
Institutions
- Université Claude Bernard Lyon 1 (FR)
- École Normale Supérieure de Lyon (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Lyon College (US)
- Hôpital de la Croix-Rousse (FR)
- Hospices Civils de Lyon (FR)
- Laboratoire de Biométrie et Biologie Evolutive (FR)
- Centre International de Recherche en Infectiologie (FR)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1007/s40262-025-01479-3
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Agence Nationale de la Recherche
- Hospices Civils de Lyon