Synthesis, Modification, and In Vitro Antimicrobial Activity of 3,4-Dihydro-4,6-diaryl-2-pyrimidinethiones
Abstract A series of 3,4-dihydro-4,6-diaryl-2-pyrimidinethiones was obtained using a three-component reaction and their modifiaction with dimethyl chloroethynylphosphonate was performed. It was shown that the phosphonylation reaction occurs under mild conditions and chemo- and regioselectively leads to bicyclic products, namely dimethyl 5,7-diaryl-5 H -thiazolo[3,2- a ]pyrimidine-3-phosphonates. Antimicrobial activity of the synthesized compounds against Staphylococcus aureus and Pseudomonas aeruginosa bacteria and yeast-like fungi Candida utilis was studied.
Authors
- Ekaterina Chernova (ORCID: https://orcid.org/0000-0002-2135-4540)
- A. S. Skrylkova
- D. M. Egorov (ORCID: https://orcid.org/0000-0003-3744-9306)
- И. Л. Кузикова (ORCID: https://orcid.org/0000-0001-6199-3104)
- Z. А. Zhakovskaya (ORCID: https://orcid.org/0000-0002-5620-1317)
- A. S. Krylov (ORCID: https://orcid.org/0000-0003-1773-7802)
Institutions
- Russian Academy of Sciences (RU)
- State Research Center of the Russian Federation (RU)
- St. Petersburg State Technological Institute (RU)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1134/s1070363224120077
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Russian Science Foundation