Identification and Synthesis of a New L-Carnitine Impurity
L-Carnitine is an endogenous substance essential for energy metabolism in mammals and a drug for the treatment of cardiovascular and neurological diseases. In this study, we reported and characterized a new impurity of L-carnitine (3-ethoxy-4-trimethylammonium 2-butenoate). The compound was synthesized from ethyl 4-chloroacetoacetate by a three-step reaction. It can be used as the impurity reference for the quality study and control of L-carnitine.
Authors
- Xiaoyu Qiu (ORCID: https://orcid.org/0000-0001-7952-3346)
- Shicheng Yan (ORCID: https://orcid.org/0000-0002-3432-9117)
- Z. Chen (ORCID: https://orcid.org/0000-0001-8982-1515)
- Xuefeng Wang (ORCID: https://orcid.org/0000-0001-6588-997X)
- Jieqiong Hou (ORCID: https://orcid.org/0000-0002-0627-7268)
Institutions
- Jiangsu Nhwa Pharmaceutical (China) (CN)
- Changzhou University (CN)
Publication Details
- Journal
- Russian Journal of General Chemistry
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1134/s1070363224120351
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00