Convergent Synthesis of OH-Terminated Water-Soluble Dendrimers Based on Imidazole-4,5-dipropargyl-diamide

In the present work, a first-generation dendron, based on imidazole-4,5-dipropargyl-diamide, was synthesized using the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. By alkylation of imidazole-4,5-dipropargyl-diamide with dibromopropane, a bis-imidazole core was obtained and used for the CuAAC-based synthesis of G0 and G1 dendrimers containing terminal OH groups. The structures and compositions of all substances were determined using modern physical methods including two-dimensional NMR and high-resolution mass spectrometry.