<scp>CSF</scp> cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (<scp>GFAP</scp>) autoimmunity

Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP-IgG-positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio-Techne). Controls included non-inflammatory (N = 42), AQP4-IgG-positive (N = 83), CNS infections (N = 13), and neurosarcoidosis (N = 32). IL5, IL6, IL10, IL8/CXCL8, CXCL9, CXCL10, CXCL13, BAFF, GM-CSF, IFN-gamma, and TNF-alpha concentrations were higher compared to non-inflammatory controls (P < 0.01). GFAP concentrations were similar to those of AQP4-IgG-positive patients; NfL was higher (P < 0.001) and correlated with MRI changes and outcomes. CSF cytokine/chemokine findings in GFAP autoimmunity correlate with histopathology; GFAP and NfL hold promise as disease biomarkers.

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Publication Details

Journal
Annals of Clinical and Translational Neurology
Published
2025-01-27
DOI
https://doi.org/10.1002/acn3.52305
Citations
6
Primary Topic
S100 Proteins and Annexins
Type
article
Field-Weighted Citation Impact
4.84

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article

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

Yahel Segal‬‏, Michel B. Tolédano, Binxia Yang, Αναστασία Ζεκερίδου et al.
6 citations
Annals of Clinical and Translational Neurology
S100 Proteins and Annexins
4.84
article

CSF cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (GFAP) autoimmunity

Yahel Segal‬‏, Michel B. Tolédano, Binxia Yang, Αναστασία Ζεκερίδου, Georgios Mangioris, Ivana Vodopivec, Eoin P. Flanagan, Andrew B. McKeon, Vanda A. Lennon, John R. Mills, Sean Joseph Pittock, Divyanshu Dubey
article en
6 citations

Abstract

Defining the CSF cytokine/chemokine and injury biomarker signature of glial fibrillary acidic protein (GFAP) autoimmunity can inform immunopathogenesis. CSF GFAP-IgG-positive samples (N = 98) were tested for 17 cytokines/chemokines, neurofilament light chain (NfL), and GFAP (ELLA, Bio-Techne). Controls included non-inflammatory (N = 42), AQP4-IgG-positive (N = 83), CNS infections (N = 13), and neurosarcoidosis (N = 32). IL5, IL6, IL10, IL8/CXCL8, CXCL9, CXCL10, CXCL13, BAFF, GM-CSF, IFN-gamma, and TNF-alpha concentrations were higher compared to non-inflammatory controls (P < 0.01). GFAP concentrations were similar to those of AQP4-IgG-positive patients; NfL was higher (P < 0.001) and correlated with MRI changes and outcomes. CSF cytokine/chemokine findings in GFAP autoimmunity correlate with histopathology; GFAP and NfL hold promise as disease biomarkers.

Annals of Clinical and Translational NeurologyVol. 12(4)
Roche (Switzerland) (CH), Mayo Clinic (US)
Mayo Clinic, National Institutes of Health, Genentech
Good health and well-being
Openalex Percentile: Top 6%
S100 Proteins and Annexins
4.84
DOIOpen Access PDFOpenAlex
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<scp>CSF</scp> cytokine, chemokine and injury biomarker profile of glial fibrillary acidic protein (<scp>GFAP</scp>) autoimmunity — Yahel Segal‬‏, Michel B. Tolédano, et al. · Annals of Clinical and Translational Neurology (2025) | TGRS Research Map | TGRS