Childhood body size, adulthood adiposity, underlying mechanisms, and risk of incident hypertension: a prospective cohort study of 180,527 participants
Thinner or plumper body size in childhood increases the risk of incident adulthood hypertension, and adulthood adiposity partly mediated this association, suggesting the importance of maintaining normal weight across the life course. Several biochemical indices and metabolites mediated these associations providing clues to underlying biological mechanisms.
Authors
- Yongfu Yu (ORCID: https://orcid.org/0000-0003-4208-9480)
- Ye Yao (ORCID: https://orcid.org/0000-0001-6240-9539)
- Shujing Ma
- Min Zhao
- Ruilang Lin
- Bo Xi (ORCID: https://orcid.org/0000-0003-0491-5585)
- Costan G. Magnussen (ORCID: https://orcid.org/0000-0002-6238-5730)
- Xue Liu
Institutions
- Qingdao University (CN)
- Baker Heart and Diabetes Institute (AU)
- University of Turku (FI)
- University of South Australia (AU)
- Fudan University (CN)
- Turku University Hospital (FI)
- Jining First People's Hospital (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- Qingdao Women and Children's Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s12916-025-03884-8
- Citations
- 4
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 13.98
Funders
- Shandong University