Multicomponent Electrosynthesis of Enaminyl Sulfonates Starting from Alkylamines, SO<sub>2</sub>, and Alcohols
An electrochemical one-pot synthesis of enaminyl sulfonate esters was established, featuring a quasidivided cell under constant current conditions. The multicomponent reaction utilizes simple and readily available alkylamines and an easy-to-use stock solution of SO<sub>2</sub> and alcohols. Omission of additional supporting electrolyte through in-situ-generated monoalkylsulfite facilitates the downstream processing. A diverse scope with more than 28 examples and yields up to 85% as well as a 20-fold scale-up reaction prove the feasibility of this novel protocol.
Authors
- Thomas Weyhermüller (ORCID: https://orcid.org/0000-0002-0399-7999)
- Aloisio de Andrade Bartolomeu (ORCID: https://orcid.org/0000-0002-8191-778X)
- Siegfried R. Waldvogel (ORCID: https://orcid.org/0000-0002-7949-9638)
- Florian A. Breitschaft
- Christian Krumbiegel
- Alicia L. Saak
Institutions
- Karlsruhe Institute of Technology (DE)
- Johannes Gutenberg University Mainz (DE)
- Max Planck Institute for Chemical Energy Conversion (DE)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1021/acs.orglett.4c04746
- Citations
- 6
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- Bundesministerium für Bildung und Forschung
- Max-Planck-Gesellschaft