METABOLIC CHANGES WHEN APPLYING AMILMETACREZOL IN THE EXPERIMENT

Respiratory diseases are among the most urgent problems of veterinary and human medicine. Many authors suggest that against the background of high air contamination in the area where animals are kept, timely treatment of diseases of the nasopharyngeal zone will limit the aerogenic pathway of damage to the lower respiratory tract. Currently, antiseptics are most often used for this purpose, in particular amimetacresol. The purpose of research is an experimental study of the effect of amylmethacresol on the state of the liver in laboratory animals. Under the conditions of the vivarium of the Federal State Budgetary Educational Institution of Higher Education St. Petersburg State University of Veterinary, a research work was carried out, the object of which were white non-linear rats aged from 3 to 5 months weighing 180–220 g. Two groups of 6 animals each were formed from clinically healthy rats: No. 1 (control, intact) - the study drug was not used in animals; № 2 (experimental) – amylmetacresol was administered orally once a day at a dose of 30 mg/kg for 7 days. In rats from the experimental group, significant changes in blood composition were noted. So, on the 8th day of the experiment, in comparison with the initial state, there was a significant increase in the level of alkaline phosphatase by 20.9 %, glucose by 10.6, cholesterol by 30.9, bilirubin by 25.9 % and bile acids by 2.3 times. A change in the activity of aminotransferases caused dysfermentemia, as indicated by a decrease in the De Ritis coefficient. There was a trend towards a decrease in total protein (by 3.3 %) and a pronounced, but not significant increase in cholesterol (by 30.9 %, p > 0.5). Our data indicate that amylmetacresol has a hepatotoxic effect and the need for its further study.