Photo‐Induced 3‐Alkylation of Coumarins with Alkyl Halides
Abstract A method for the direct 3‐alkylation of coumarins utilizing alkyl halides as the alkylating agents has been achieved. This versatile reaction is compatible with a range of alkyl halides, including activated alkyl bromides, perfluoroalkyl iodides, and unactivated alkyl iodides. We propose a mechanism involving photoinduced electron transfer between alkyl halides and coumarins in the first singlet excited (S 1 ) state, which generates alkyl radicals essential for the 3‐alkylation process.
Authors
- Wanbin Zhang (ORCID: https://orcid.org/0000-0002-4788-4195)
- Xiaojun Tang (ORCID: https://orcid.org/0000-0002-3716-0601)
- Weiguo Cao (ORCID: https://orcid.org/0000-0002-6482-2877)
- Liu‐Yan Qiu
- Rui Wang (ORCID: https://orcid.org/0000-0002-1864-3173)
- Zhikun Zhang (ORCID: https://orcid.org/0000-0002-0591-3680)
- Yan Cheng
Institutions
- Shanghai University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1002/adsc.202401579
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Natural Science Foundation of China
- Dalian University of Technology