TUBB3 Expression in Nonsmall Cell Lung Cancer Tissue: Reasons for Immunohistochemical Assay Discordance and an Approach to Overcome It
The reasons for discordance data on the contribution of a TUBB3 microtubule protein to resistance to antitumor drugs and the metastatic potential of tumors with an assessment of prognostic significance of TUBB3 expression in nonsmall cell lung cancer tissue are analyzed. The need to introduce quantitative analysis methods in molecular diagnostics of tumors (in particular, immunofluorescence assessment associated with flow cytometry) is substantiated.
Authors
- T. A. Bogush
- A. Lee (ORCID: https://orcid.org/0009-0006-3161-0153)
- В. С. Косоруков (ORCID: https://orcid.org/0000-0002-8462-2178)
- E. A. Bogush
- S. A. Kaliuzhny (ORCID: https://orcid.org/0000-0002-8701-7707)
- M. Ya. Melnikov
Institutions
- Sechenov University (RU)
- Lomonosov Moscow State University (RU)
- Ministry of Health of the Russian Federation (RU)
Publication Details
- Journal
- Moscow University Chemistry Bulletin
- Published
- 2024-12-01
- DOI
- https://doi.org/10.3103/s0027131424700457
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.70