hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling
hUC-MSC contribute to the recovery of erectile function in CNI-ED rats by restoring mitochondrial mass and function of CCSMCs through the SIRT1/PGC-1α/TFAM pathway. Our present study offers new insights into the role and molecular mechanisms of hUC-MSC in regulating mitochondrial homeostasis, thereby facilitating the restoration of the erectile function in CNI-ED.
Authors
- Xinda Chen
- Dongdong Xiao (ORCID: https://orcid.org/0000-0002-7962-3846)
- Xiaolin Zhang (ORCID: https://orcid.org/0000-0002-2908-5920)
- Ming Zhang (ORCID: https://orcid.org/0009-0002-5445-3294)
- Mujun Lu (ORCID: https://orcid.org/0000-0002-3404-1260)
- Mengbo Yang
- Huiming Xu
Institutions
- Shanghai Jiao Tong University (CN)
- Renji Hospital (CN)
Publication Details
- Journal
- Biological Research
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s40659-024-00578-y
- Citations
- 7
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- National Natural Science Foundation of China