A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration
Lipo-MP-LPS inhibited tumour growth and lung metastasis of osteosarcoma by promoting CD8 + T cell infiltration, indicating its therapeutic potential for advanced osteosarcoma.
Authors
- Nobuhiko Yokoyama (ORCID: https://orcid.org/0000-0002-3013-3205)
- Jérôme Kerzerho (ORCID: https://orcid.org/0000-0002-0523-8267)
- Makoto Endo (ORCID: https://orcid.org/0000-0002-7956-2190)
- Yoshinao Oda (ORCID: https://orcid.org/0000-0001-9636-1182)
- Toshifumi Fujiwara (ORCID: https://orcid.org/0000-0001-9381-9696)
- Martine Caroff (ORCID: https://orcid.org/0000-0002-7329-5247)
- Ryunosuke Oyama (ORCID: https://orcid.org/0000-0001-7527-2463)
- Capucine Phelip (ORCID: https://orcid.org/0000-0001-7803-505X)
- Yoshihiro Matsumoto (ORCID: https://orcid.org/0000-0002-0039-2855)
- А. В. Новиков (ORCID: https://orcid.org/0000-0002-6667-8098)
- Yasuharu Nakashima
- Akira Nabeshima (ORCID: https://orcid.org/0009-0004-0508-7309)
Institutions
- Fukushima Medical University (JP)
- Kyushu University (JP)
- Université Paris-Saclay (FR)
Publication Details
- Journal
- BJC Reports
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1038/s44276-024-00120-3
- Citations
- 4
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Japan Society for the Promotion of Science