Synergistic Cancer Photoimmunotherapy by Harnessing Near‐Infrared‐Activated Nanoparticles Containing Charge Transfer Complexes

Phototherapy-which includes photothermal therapy (PTT) and photodynamic therapy (PDT)-has evoked interest as a promising cancer treatment modality on account of its noninvasiveness, spatiotemporal precision, and minimal side effects. C. Wang et al. recently reported a near-infrared-activated charge transfer complex-based nanoparticle which consists of a donor (D) and an acceptor (A). Experimental results have demonstrated a potent immunotherapeutic effect of integrating programmed cell death protein 1 antibody combination therapy in preclinical models. Incorporating D-A interactions into nanosystems for photoimmunotherapy (PIT) is still a novel approach. This approach offers a multifaceted strategy for synergistic cancer PIT which holds promising potential to transform cancer treatment paradigms.