The effectiveness of the use of adaptogenic drugs for adaptation of patients with depressive neurosis to fixed orthopedic prosthetics.

Disturbed adaptation mechanisms in the body in patients with depressive neurosis lead to a lack of adequate perception of the new fixed orthopedic prosthetics in the oral cavity and patients’ demands for their replacement due to complaints of various types of discomfort that do not have clinical evidence. Patients refusal of necessary psychoneurological treatment forces dentists to use additional methods for correcting the body’s adaptive mechanisms. The purpose of the study was to evaluate the adaptation to fixed orthopedic prosthetics in patients with depressive neurosis taking adaptogenic drugs. Materials and methods. The study was conducted on the basis of the Federal State Budgetary Educational Institution of Higher Education “Russian University of Medicine” of the Ministry of Health of the Russian Federation. The study included 80 patients aged 18 to 44 years of both sexes with a diagnosis of ICD 10 F34.1 – depressive neurosis confirmed by a neurologist and psychiatrist, but who refused full-fledged specialized psychoneurological treatment due to mistrust of pharmaceutical drugs that affect the central nervous system and possible complications that a patient may encounter after taking antidepressants. The study was approved by the Interuniversity Ethics Committee on 13.04.23 (Extract from protocol no. 04–23). The first group included patients to whom a neurologist and psychiatrist prescribed a course of the adaptogenic drug Stimol (citrulline malate) for a period of 12 days. After completing the course of taking the drug, we carried out rational prosthetics of destroyed non-vital teeth with all-ceramic E.max crowns. The second group includes patients who also had their damaged teeth restored with all-ceramic E.max crowns, but without prior correction of the adaptation mechanisms with adaptogenic drugs. The effectiveness of adaptation to fixed orthopedic prosthetics was assessed using the “Protocol for dynamic assessment of patient adaptation to dental prosthetics” [8]. Results. As a result of the study, adaptation occurred in 75 % of patients in the first group, and in 15 % in the second group. Conclusion. The need for pharmacological correction of adaptation mechanisms in patients with depressive disorder was confirmed. In the study group of patients, the optimal level of adaptation was achieved with taking the adaptogenic drug «Stimol».