Molecular Subtyping for Predicting Pathological Upstaging and Survival Outcomes in Clinically Organ-confined Bladder Cancer Patients Undergoing Radical Cystectomy
Molecular subtyping suggests that in clinically non-muscle-invasive bladder cancer, luminal tumors harbor less aggressive disease, as reflected by lower rates of pathological upstaging to muscle-invasive disease and favorable outcomes with radical cystectomy, in comparison with nonluminal bladder cancer.
Authors
- Elai Davicioni (ORCID: https://orcid.org/0000-0001-9136-099X)
- Robert S. Svatek (ORCID: https://orcid.org/0000-0002-0239-1338)
- Shreyas Joshi (ORCID: https://orcid.org/0000-0002-0020-5298)
- Ewan A. Gibb (ORCID: https://orcid.org/0000-0001-9836-1434)
- Yair Lotan (ORCID: https://orcid.org/0000-0001-5692-2723)
- Siamak Daneshmand (ORCID: https://orcid.org/0000-0001-6224-9598)
- Joep J. de Jong (ORCID: https://orcid.org/0000-0003-2378-367X)
- Brant A. Inman (ORCID: https://orcid.org/0000-0002-6060-4485)
- Roger Li (ORCID: https://orcid.org/0000-0003-1274-7200)
- Vikram M. Narayan (ORCID: https://orcid.org/0000-0003-3731-4209)
- Aaron Dahmen (ORCID: https://orcid.org/0000-0001-8314-4576)
- Jonathan Lawrence Wright (ORCID: https://orcid.org/0000-0002-8447-8209)
- Iftach Chaplin
- Paras Shah (ORCID: https://orcid.org/0000-0003-3855-7747)
- James A. Proudfoot (ORCID: https://orcid.org/0009-0008-7063-5761)
Institutions
- University of Southern California (US)
- Western University (CA)
- Emory University (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Washington (US)
- Erasmus MC (NL)
- Moffitt Cancer Center (US)
- Veracyte (United States) (US)
- Mayo Clinic in Arizona (US)
- The University of Texas at San Antonio (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.euros.2024.12.009
- Citations
- 3
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Wilson Foundation
- Erasmus Medisch Centrum