SLC26A9 promotes the initiation and progression of breast cancer by activating the PI3K/AKT signaling pathway
SLC26A9 is a member of the Slc26a family of multifunctional anion transporters that function as Cl<sup>-</sup> channels in the stomach. We reported for the first time that SLC26A9 is involved in gastric tumorigenesis. However, the role of SLC26A9 in breast cancer has not yet been investigated. We first demonstrated that the upregulation of SLC26A9 is associated with the clinicopathological progression and poor prognosis of patients with breast cancer and is positively correlated with HER2 amplification. SLC26A9 alters the proliferation, migration, and invasion potential of breast cancer cells by regulating the PI3K/AKT signaling pathway. SLC26A9 acts as an oncogene in the development of breast cancer. These findings provide valuable insights for the development of future diagnostic and therapeutic strategies for BC.
Authors
- Yingying Zhao (ORCID: https://orcid.org/0000-0002-6566-1841)
- Peng Yuan (ORCID: https://orcid.org/0000-0003-4627-8203)
- Zhiqiang Yi (ORCID: https://orcid.org/0009-0008-7363-4342)
- Hai Jin (ORCID: https://orcid.org/0000-0003-0430-2834)
- Jiaxing An (ORCID: https://orcid.org/0000-0002-0988-9972)
- Renmin Mu
- Biguang Tuo (ORCID: https://orcid.org/0000-0003-3147-3487)
- Zhengxing Zhou (ORCID: https://orcid.org/0000-0001-8507-3660)
- Zilin Deng
- Taolang Li (ORCID: https://orcid.org/0000-0001-8150-7687)
- Minglin Zhang (ORCID: https://orcid.org/0000-0002-5881-3544)
- Hu Wang
- Xuemei Liu (ORCID: https://orcid.org/0000-0002-3104-4343)
- Zhiyuan Ma (ORCID: https://orcid.org/0000-0002-0750-9307)
- Jiaxing Zhu (ORCID: https://orcid.org/0000-0001-6143-5807)
- Chengmin Zhang (ORCID: https://orcid.org/0000-0002-9913-111X)
- Guorong Wen
- Chengli Lu
Institutions
- Zunyi Medical University (CN)
Publication Details
- Journal
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.bbamcr.2025.119912
- Citations
- 2
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61