Synthetic Studies of Polycyclic Polyprenylated Acylphloroglucinols: Asymmetric Construction of a Cyclohexanone Moiety
Abstract As a common intermediate for polycyclic polyprenylated acylphloroglucinols (PPAPs), we successfully synthesized a cyclohexanone moiety that contains two adjacent stereocenters, one of which is a quaternary carbon. Our synthetic strategy relied on an asymmetric Claisen rearrangement using Oppolzer’s camphorsultam and a regioselective Dieckmann condensation.
Authors
- Ken‐ichi Takao (ORCID: https://orcid.org/0000-0001-8629-1002)
- Kohei Abo
- Genichiro Okuyama
- Daisuke Aoki (ORCID: https://orcid.org/0000-0002-7272-0643)
- Takashi Akiya
- Akihiro Ogura (ORCID: https://orcid.org/0000-0002-4793-5706)
- Keisuke Yoshida (ORCID: https://orcid.org/0000-0002-8384-9418)
- Satoshi Nanataki
- Hayato Onozawa
Institutions
- Keio University (JP)
- Meijo University (JP)
Publication Details
- Journal
- Synlett
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1055/a-2526-0619
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science