Chelidonine overcomes P-gp-mediated adriamycin resistance in MCF-7/ADR cells by inhibiting PDGFRβ/PI3K/Akt pathway
These findings underscore the potential role of PDGFR<i>β</i> in regulating chemotherapy resistance in BC. Chelidonine could effectively overcome the resistance of MCF-7/ADR cells to ADR by targeting the PDGFR<i>β</i>/PI3K/Akt axis. Meanwhile, these findings highlight the potential of chelidonine as a promising natural chemoresistant agent for BC treatment.
Authors
- Yuhang Zhang (ORCID: https://orcid.org/0000-0002-9738-5343)
- Liyue Zhang (ORCID: https://orcid.org/0000-0001-6679-4411)
- Yue Zhang (ORCID: https://orcid.org/0000-0001-8265-6721)
- Jianli Li (ORCID: https://orcid.org/0000-0002-9518-9832)
- Lei Yu (ORCID: https://orcid.org/0000-0001-8773-731X)
- Xiang Zou (ORCID: https://orcid.org/0009-0001-4095-4402)
- Kai‐Li Liu (ORCID: https://orcid.org/0000-0003-3370-842X)
- Zhongyuan Qu (ORCID: https://orcid.org/0000-0001-9666-3957)
- Xuerui Zhang (ORCID: https://orcid.org/0009-0003-2779-0583)
Institutions
- Harbin University of Commerce (CN)
Publication Details
- Journal
- Chinese Herbal Medicines
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.chmed.2025.01.005
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00