Autophagy activation within inflammatory microenvironment improved the therapeutic effect of MSC-Derived extracellular Vesicle in SLE
We developed a novel strategy to improve the therapeutic efficacy of MSC-EVs in SLE and confirmed that the immunomodulatory function of the MSC-EVs is enhanced through autophagic activation and interaction with the SLE serum microenvironment, a process likely benefited by the high expression of IDO1.
Authors
- Howard J. Huang (ORCID: https://orcid.org/0000-0002-3358-6795)
- Jiaxuan Chen (ORCID: https://orcid.org/0000-0001-5801-9052)
- Lawei Yang
- Qingjun Pan (ORCID: https://orcid.org/0000-0002-8060-9099)
- Yugan Guo
- Fengbiao Guo
- Zengzhi Xiao
- Shuzhen Liao
- Shuting Wang (ORCID: https://orcid.org/0000-0003-1461-3898)
- Huafeng Liu (ORCID: https://orcid.org/0000-0002-9737-9437)
- Qifang Pan (ORCID: https://orcid.org/0000-0002-8183-4343)
- Xi Wang (ORCID: https://orcid.org/0000-0002-0322-5577)
- Haiyan Xiao (ORCID: https://orcid.org/0000-0003-2878-337X)
Institutions
- Guangdong Medical College (CN)
- Augusta University (US)
- Shantou University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Yue Bei People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.jare.2025.01.044
- Citations
- 4
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province