Uridine-cytidine kinase 2 is correlated with immune, DNA damage repair and promotion of cancer stemness in pan-cancer
We have observed that UCK2 plays pivotal roles in prognosis and tumor immunity, and it is associated with DNA repair and cancer stemness. The UCK2 gene exhibits a strong correlation with the immune checkpoints HLA. This study highlights its potential impact on drug sensitivity.
Authors
- Jinlong Tian (ORCID: https://orcid.org/0000-0001-7149-9441)
- Tingxiao Zhao (ORCID: https://orcid.org/0000-0003-0154-3595)
- Qing Bi (ORCID: https://orcid.org/0000-0002-5472-1212)
- Yanlei Li (ORCID: https://orcid.org/0000-0002-8374-8430)
- Tong Yu (ORCID: https://orcid.org/0009-0002-1924-1325)
- Yao Kang (ORCID: https://orcid.org/0000-0001-5251-4116)
- Yuan Zhang
Institutions
- Bengbu Medical College (CN)
- Zhejiang Provincial People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.3389/fonc.2025.1503300
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81