Modern Approaches for Asymmetric Construction of CF₃‐All Carbon Quaternary Stereocenters from Prochiral Trifluoromethyl Alkenes

Abstract At present, the research of organofluorine chemistry is a leading and rapidly emerging area of life sciences. Organofluorine molecules have drawn much attention by displaying a wide variety of applications in agrochemicals, medicines, fire extinguishers, and blowing agents. In the present review, the great advances made in the last decade for the asymmetric construction of quaternary stereocenters bearing trifluoromethyl group from the corresponding prochiral‐trifluoromethylated substrates are discussed. A variety of catalytic frameworks have been designed in this field for asymmetric induction. The main prochiral‐trifluoromethyl substrates chosen for this review are β ‐CF 3 ‐ β ‐substituted nitro alkenes and α, β ‐ unsaturated trifluoromethyl ketones. Moreover, this review describes the further utilization of obtained CF 3 ‐quaternary centres to access the important organofluorine molecules.