The gut–kidney axis is regulated by astragaloside IV to inhibit cyclosporine A-induced nephrotoxicity
AS-IV improved CICN through the coexpression of the gut-transcriptome-metabolome network. The six pathways related to energy metabolism driven by <i>L. reuteri</i>, including the <i>citrate cycle</i>, <i>ascorbate and alderate metabolism</i>, <i>proximal tube bicarbonate metabolism</i>, <i>glycolysis/gluconeogenesis, ferroptosis, drug metabolism-cytochrome P450</i>, are important mechanisms.
Authors
- Le Zhou (ORCID: https://orcid.org/0000-0002-9647-7924)
- Ranran Gao (ORCID: https://orcid.org/0000-0002-7164-0289)
- Cong Han (ORCID: https://orcid.org/0000-0001-6641-5813)
- Wei Li (ORCID: https://orcid.org/0000-0002-9025-7293)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.3389/fphar.2025.1518481
- Citations
- 8
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 10.55
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation