Transcriptome analysis reveals effects of ethynylestradiol and bisphenol A on multiple endocrine and metabolic pathways in the pituitary and liver of female Atlantic cod (Gadus morhua)
The results suggest that estrogenic compounds affect a broad range of reproductive and metabolic processes in the pituitary. The alterations in the liver unravel the transcriptional changes underlying metabolic remodeling during estrogen induced vitellogenesis. This study provides new insights into mechanisms of endocrine and metabolic interactions that can be potential targets of environmental estrogens in fish. The study also identifies potential gene expression biomarkers for pituitary and liver effects of xenoestrogens.
Authors
- Fekadu Yadetie (ORCID: https://orcid.org/0000-0002-2484-9047)
- Inge Jonassen (ORCID: https://orcid.org/0000-0003-4110-0748)
- Jon Vidar Helvik (ORCID: https://orcid.org/0000-0002-9276-7430)
- Mitchell S. Fleming (ORCID: https://orcid.org/0000-0002-8644-8433)
- Anders Goksøyr (ORCID: https://orcid.org/0000-0003-4054-9842)
- Mariann Eilertsen (ORCID: https://orcid.org/0000-0002-4485-2024)
- Xiaokang Zhang (ORCID: https://orcid.org/0000-0003-4684-317X)
- Odd André Karlsen (ORCID: https://orcid.org/0000-0003-0075-6601)
- Anna Reboa
- Gwenaëlle Samantha Chloe Noally
Institutions
- University of Bergen (NO)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.3389/fendo.2024.1491432
- Citations
- 2
- Primary Topic
- Reproductive biology and impacts on aquatic species
- Type
- article
- Field-Weighted Citation Impact
- 2.24
Funders
- Trond Mohn stiftelse
- Universitetet i Bergen
- Norges Forskningsråd