Plasma IL-17A is increased in patients with critical MIS-C and associated to in-hospital mortality
A total of 41 patients out of 109 patients admitted at PICU with suspected MIS-C during the study period were included, of which 33 (80.5%) were male, 9 (22%) were under one year old, and 30 (73.2%) presented comorbidities. Among them, 16 (39%) did not survive. The mean survival time was shorter in patients with higher levels of IL-17A (≥ 19.71 pg/mL) on day 1 (115 vs 323 days, p = 0.004). Higher levels of IL-17A on day 1 were associated with mortality in both the crude model (HR 1.03, CI95% 1.004-1.057, p = 0.022) and the adjusted model (HR 1.043, CI95% 1.013-1.075, p = 0.012). ROC analysis revealed a cut-off value for the IL-17A of 14.32 pg/ml. The other immunological and inflammatory markers did not demonstrate an association with survival (p>0.05). Our findings suggest that patients with high levels of IL-17A are at greater risk for death.
Authors
- Dalila C.A. Pavão (ORCID: https://orcid.org/0000-0001-6126-9933)
- Marília C. B. Alves
- Mary L. F. M. F. de Mello
- Sara M P de Moraes
- Gabriela Arruda Reinaux Pontes
- Ana P. S. Pinheiro
- Iran Barros Costa (ORCID: https://orcid.org/0000-0003-3697-0554)
- Jean Leandro dos Santos (ORCID: https://orcid.org/0000-0002-2460-2829)
- L.M.P.P. Do Nascimento (ORCID: https://orcid.org/0000-0002-7880-4039)
- Railana D. F. P. Carvalho
- Manoel Jaime Castro Pavão Júnior (ORCID: https://orcid.org/0000-0001-5685-9947)
- Larissa Borges e Silva (ORCID: https://orcid.org/0009-0001-8011-9460)
- Patrícia Barbosa de Carvalho (ORCID: https://orcid.org/0000-0002-6157-2083)
- A. Sousa (ORCID: https://orcid.org/0009-0008-9064-2803)
- Marta Chagas Monteiro (ORCID: https://orcid.org/0000-0002-3328-5650)
- Igor Brasil-Costa
- Maria Cleonice Aguiar Justino (ORCID: https://orcid.org/0000-0003-3248-5893)
- M Serrão (ORCID: https://orcid.org/0000-0002-7893-0043)
- Cristiane T. C. Silva
- Larisse F. Q. Aires
- Luana G. Dias
- Gleice Clemente (ORCID: https://orcid.org/0000-0001-7824-437X)
- Cibele Ferreira Neves
- Kíssila Márvia MM Ferraro
- Emmerson Carlos Franco de Farias (ORCID: https://orcid.org/0000-0001-8627-5694)
- Mayara M. M. Machado
- Regina Lúcia Elia Gomes (ORCID: https://orcid.org/0000-0002-6247-9673)
- Renata de B Braga
- K. Harada
- Maria Teresa Terreri
- A. Viana Pinheiro
Institutions
- Amazon Research Foundation (BR)
- Ministério da Saúde (BR)
- Instituto Evandro Chagas (BR)
- Universidade Federal do Pará (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.3389/fimmu.2024.1485009
- Citations
- 1
- Primary Topic
- Kawasaki Disease and Coronary Complications
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Directorate for Biological Sciences