Liposomal encapsulation of cholecalciferol mitigates in vivo toxicity and delays tumor growth
Liposomal encapsulation of vitamin D<sub>3</sub> significantly improves its anticancer efficacy while mitigating toxicity, making it a promising strategy for future cancer therapies. VD-LP shows potential for enhanced therapeutic applications with reduced adverse effects, warranting further clinical exploration.
Authors
- Alexandra M. Vázquez-Salgado (ORCID: https://orcid.org/0000-0002-5946-0250)
- Nuria Ardaiz (ORCID: https://orcid.org/0000-0002-9168-553X)
- Celia Gomar (ORCID: https://orcid.org/0000-0001-7864-9481)
- Leire Arrizabalaga (ORCID: https://orcid.org/0000-0003-0423-8350)
- Virginia Belsúe (ORCID: https://orcid.org/0000-0002-7939-8415)
- Marı́a J. Garrido (ORCID: https://orcid.org/0000-0003-3559-4710)
- Pedro Berraondo (ORCID: https://orcid.org/0000-0001-7410-1865)
- Sara Zalba (ORCID: https://orcid.org/0000-0001-5203-2985)
- Fernando Aranda (ORCID: https://orcid.org/0000-0002-9364-474X)
- Ángela Bella (ORCID: https://orcid.org/0000-0002-6534-7705)
- Aline Risson
- Miriam Ezcurra-Hualde
- David Ruiz-Guillamon
- Alejandro Serrano-Alcaide (ORCID: https://orcid.org/0000-0003-1565-4325)
- Román García-Fuentes
Institutions
- Navarre Institute of Health Research (ES)
- Clinica Universidad de Navarra (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1529007
- Citations
- 2
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- European Commission
- Gobierno de Navarra
- Instituto de Salud Carlos III
- European Social Fund