Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from November to December 2023

This study highlights the complexity of CRKP outbreaks in neonatal care, with isolates exhibiting resistance mechanisms that complicate treatment. The plasmid profiles suggest these strains are reservoirs for multidrug-resistant genes, emphasizing the need for strict infection control and ongoing genomic surveillance. For neonatal care, these resistance challenges increase the risk of treatment failures and mortality, underscoring the importance of enhanced infection prevention and novel therapeutic strategies.

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Publication Details

Journal
Frontiers in Cellular and Infection Microbiology
Published
2025-01-27
DOI
https://doi.org/10.3389/fcimb.2024.1528017
Citations
6
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
3.55
Controls
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article

Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from November to December 2023

Xiaoming Zhou, Wei Lei, Guangxin Lv, Devender Sharma et al.
6 citations
Frontiers in Cellular and Infection Microbiology
Antibiotic Resistance in Bacteria
3.55
article

Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from November to December 2023

Xiaoming Zhou, Wei Lei, Guangxin Lv, Devender Sharma, Kailash Wagh
article en
6 citations

Abstract

This study highlights the complexity of CRKP outbreaks in neonatal care, with isolates exhibiting resistance mechanisms that complicate treatment. The plasmid profiles suggest these strains are reservoirs for multidrug-resistant genes, emphasizing the need for strict infection control and ongoing genomic surveillance. For neonatal care, these resistance challenges increase the risk of treatment failures and mortality, underscoring the importance of enhanced infection prevention and novel therapeutic strategies.

Frontiers in Cellular and Infection MicrobiologyVol. 14
Sri Dharmasthala Manjunatheshwara College of Dental Sciences & Hospital (IN), Dr. D. Y. Patil Medical College, Hospital and Research Centre (IN), Dongguan People’s Hospital (CN)
Good health and well-being
Openalex Percentile: Top 8%
Antibiotic Resistance in Bacteria
3.55
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Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from November to December 2023 — Xiaoming Zhou, Wei Lei, et al. · Frontiers in Cellular and Infection Microbiology (2025) | TGRS Research Map | TGRS