Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from November to December 2023
This study highlights the complexity of CRKP outbreaks in neonatal care, with isolates exhibiting resistance mechanisms that complicate treatment. The plasmid profiles suggest these strains are reservoirs for multidrug-resistant genes, emphasizing the need for strict infection control and ongoing genomic surveillance. For neonatal care, these resistance challenges increase the risk of treatment failures and mortality, underscoring the importance of enhanced infection prevention and novel therapeutic strategies.
Authors
- Xiaoming Zhou (ORCID: https://orcid.org/0000-0001-5597-4804)
- Wei Lei (ORCID: https://orcid.org/0000-0002-4033-4799)
- Guangxin Lv (ORCID: https://orcid.org/0000-0001-6288-5957)
- Devender Sharma (ORCID: https://orcid.org/0000-0001-9306-7893)
- Kailash Wagh
Institutions
- Sri Dharmasthala Manjunatheshwara College of Dental Sciences & Hospital (IN)
- Dr. D. Y. Patil Medical College, Hospital and Research Centre (IN)
- Dongguan People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.3389/fcimb.2024.1528017
- Citations
- 6
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 3.55