Unveiling immunogenic characteristics and neoantigens in endometrial cancer with POLE hotspot mutations for improved immunotherapy
Our study uncovers the pronounced immunogenicity of POLE-mutant EC and characterizes neoantigens that are unique to the POLE<sup>P286R</sup> mutation, thus providing a promising new immunotherapeutic strategy for EC.
Authors
- Xiaoping Miao (ORCID: https://orcid.org/0000-0002-6818-9722)
- Shuang Song (ORCID: https://orcid.org/0000-0002-5587-2880)
- Yinyan He (ORCID: https://orcid.org/0000-0002-7311-9067)
- Laman He
- Yihua Yin
- Zhigang Zhang (ORCID: https://orcid.org/0000-0001-8965-223X)
- Huimin Wang (ORCID: https://orcid.org/0000-0001-8468-2974)
- Yiran Li (ORCID: https://orcid.org/0000-0002-4658-3876)
- Xueli Zhang (ORCID: https://orcid.org/0000-0001-8306-0639)
- Xintao Wang (ORCID: https://orcid.org/0009-0002-7046-6132)
- Ye Gu (ORCID: https://orcid.org/0000-0002-9936-8125)
- Jian Huang
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Cancer Institute (CN)
- Shanghai First Maternity and Infant Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.3389/fimmu.2025.1528532
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China