FLASH proton reirradiation, with or without hypofractionation, reduces chronic toxicity in the normal murine intestine, skin, and bone
These studies provide the first evidence of the sparing effects of F-PRT in the setting of hypofractionated reirradiation. The results support FLASH as highly relevant to the reirradiation regimen where it exhibits significant potential to minimize chronic complications for patients undergoing RT.
Authors
- Brett Bell (ORCID: https://orcid.org/0000-0003-2264-0589)
- Seyyedeh Azar Oliaei Motlagh (ORCID: https://orcid.org/0000-0002-6732-8946)
- Enrico Radaelli (ORCID: https://orcid.org/0000-0002-2885-0221)
- Jiawei Lu (ORCID: https://orcid.org/0000-0002-7606-0080)
- Mary E. Putt (ORCID: https://orcid.org/0000-0001-7954-1288)
- Ioannis I. Verginadis (ORCID: https://orcid.org/0000-0002-0755-4511)
- Amit Maity (ORCID: https://orcid.org/0000-0001-7151-2845)
- Chandan Guha (ORCID: https://orcid.org/0000-0002-1906-2186)
- Anastasia Velalopoulou (ORCID: https://orcid.org/0000-0002-1166-6102)
- Keith A. Cengel (ORCID: https://orcid.org/0000-0001-6960-5882)
- James M. Metz
- Michele M. Kim (ORCID: https://orcid.org/0000-0003-1100-1298)
- Esha Banerjee (ORCID: https://orcid.org/0000-0001-7677-3702)
- Theresa M. Busch (ORCID: https://orcid.org/0000-0002-5499-8377)
- Constantinos Koumenis (ORCID: https://orcid.org/0000-0001-5945-4726)
- Ling Qin (ORCID: https://orcid.org/0000-0001-6173-6167)
- Eric S. Diffenderfer (ORCID: https://orcid.org/0000-0002-4869-6575)
- Charles‐Antoine Assenmacher (ORCID: https://orcid.org/0000-0003-0073-2730)
- Kyle Kim
- Ioannis Paraskevaidis
- Antoneta Karaj
- Giovanni Finesso
- Yuewei Lin
Institutions
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.radonc.2025.110744
- Citations
- 20
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 30.37
Funders
- University of Pennsylvania
- Institute for Translational Medicine and Therapeutics
- National Institutes of Health
- Perelman School of Medicine, University of Pennsylvania
- National Center for Advancing Translational Sciences