Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma
By defining the immunosuppressive effects of neuroblastoma's TME on CAR T-cell efficacy, revealing the pivotal role of MIF, we provide an analytic pipeline and therapeutic strategy for improving adoptive cell therapies for this pediatric malignancy and potentially other solid tumors.
Authors
- John A. Anderson (ORCID: https://orcid.org/0000-0001-7509-3203)
- Peter G. Hains (ORCID: https://orcid.org/0000-0002-7276-1760)
- Phillip J. Robinson (ORCID: https://orcid.org/0000-0002-7878-0313)
- Marta Barisa (ORCID: https://orcid.org/0000-0001-7846-6810)
- Frank J. Dekker (ORCID: https://orcid.org/0000-0001-7217-9300)
- Kristopher R. Bosse (ORCID: https://orcid.org/0000-0002-1424-2858)
- Marı́a S. Soengas (ORCID: https://orcid.org/0000-0003-0612-6299)
- Thanasis Margaritis (ORCID: https://orcid.org/0000-0003-4040-2015)
- Henrike Muller (ORCID: https://orcid.org/0000-0002-4682-4553)
- Xavier Catena (ORCID: https://orcid.org/0000-0001-7885-2447)
- Judith Wienke (ORCID: https://orcid.org/0000-0002-3835-6374)
- Qing Zhong
- Josephine G. M. Strijker (ORCID: https://orcid.org/0000-0003-4260-2942)
- Linda Schild
- Grant P. Grothusen (ORCID: https://orcid.org/0000-0001-9236-0369)
- Brendan McIntyre (ORCID: https://orcid.org/0000-0002-6473-5140)
- Lindy L. Visser (ORCID: https://orcid.org/0000-0001-7856-1981)
- Chunlong Zhao (ORCID: https://orcid.org/0000-0001-7920-8231)
- Jan J. Molenaar (ORCID: https://orcid.org/0000-0002-2007-0431)
- Rivani Shah
- Elisavet Kalaitsidou
- Guillem Pascual‐Pasto (ORCID: https://orcid.org/0000-0001-8537-261X)
- Stephanie Matlaga (ORCID: https://orcid.org/0009-0005-7463-6022)
- Yannine J. Kalmeijer
- Roger R Reddel
- Wei Wu
- Courtney Himsworth (ORCID: https://orcid.org/0000-0002-4233-7512)
Institutions
- Children's Hospital of Philadelphia (US)
- Children's Medical Research Institute (AU)
- University of Groningen (NL)
- Great Ormond Street Hospital (GB)
- Singapore Immunology Network (SG)
- Spanish National Cancer Research Centre (ES)
- Princess Máxima Center (NL)
- University College London (GB)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.ejca.2025.115263
- Citations
- 14
- Primary Topic
- Macrophage Migration Inhibitory Factor
- Type
- article
- Field-Weighted Citation Impact
- 11.16
Funders
- Alex's Lemonade Stand Foundation for Childhood Cancer
- European Commission
- Agency for Science, Technology and Research
- Koninklijke Nederlandse Akademie van Wetenschappen
- ZonMw
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Stichting Kinderen Kankervrij
- Stichting Villa Joep
- Horizon 2020 Framework Programme
- Medical Research Council
- National Medical Research Council
- Biomedical Research Council
- National Cancer Institute