Differed brain spontaneous neural activity between limb-onset and bulbar-onset amyotrophic lateral sclerosis patients
ALS-B and ALS-L patients had distinct alterations in brain spontaneous neural activity, which could serve as potential biomarkers for accurately distinguishing these two subtypes. Our findings offer a new insight into the neural mechanism of ALS, underscoring the importance of personalized diagnostic approaches for this complex neurological disorder.
Authors
- Qian Wu (ORCID: https://orcid.org/0000-0002-8638-3107)
- Qi Niu (ORCID: https://orcid.org/0000-0001-9237-9553)
- Jiang Zhou (ORCID: https://orcid.org/0000-0003-1038-387X)
- Hao Hu (ORCID: https://orcid.org/0000-0002-7983-7377)
- Xiao‐Quan Xu (ORCID: https://orcid.org/0000-0001-5493-5256)
- Qianqian Zhang (ORCID: https://orcid.org/0000-0003-3442-4461)
- Yu Zhang (ORCID: https://orcid.org/0000-0001-9628-7955)
- Qingyang Li (ORCID: https://orcid.org/0000-0003-1560-7270)
- Sijie Chen (ORCID: https://orcid.org/0000-0001-5263-9189)
- Fei-Yun Wu
Institutions
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Brain Research Bulletin
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1016/j.brainresbull.2025.111229
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China