A strategy for selective screening of dual-target bioactive compounds against hypertrophic scar through inhibiting angiotensin II type 1 receptor while stimulating type 2 receptor from Chinese herbs
We reasoned that aloe-emodin and emodin had the potential to become dual-target candidates against hypertrophic scar through the regulation of AT<sub>1</sub>R and AT<sub>2</sub>R signaling pathways. It showed considerable potential to become a universal strategy for pursuing multi-target bioactive compounds from Chinese herbs by the utilization of diverse immobilized receptors in a desired order.
Authors
- Xinfeng Zhao (ORCID: https://orcid.org/0000-0001-8824-738X)
- Lejing Qu
- Meizhi Jiao
- Yuanyuan Ou
- Zilong Zhang (ORCID: https://orcid.org/0000-0002-4934-1258)
- Yajun Zhang (ORCID: https://orcid.org/0000-0002-1182-6057)
- Xue Zhao (ORCID: https://orcid.org/0000-0001-9577-4145)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Northwest University (CN)
- Xi'an Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s13020-025-01065-6
- Citations
- 4
- Primary Topic
- Dermatologic Treatments and Research
- Type
- article
- Field-Weighted Citation Impact
- 8.02
Funders
- Shaanxi Administration of Traditional Chinese Medicine
- National Natural Science Foundation of China