Number of children and dementia risk: a causal mediation analysis using data from the HUNT study linked with national registries in Norway
Our findings suggest that the number of children-specifically being childless, having one child, or having four or more children-may influence the risk of dementia. These relationships were not mediated by psychosocial, lifestyle, and socioeconomic factors, or markers of chronic diseases in adulthood considered in this study.
Authors
- Geir Selbæk (ORCID: https://orcid.org/0000-0001-6511-8219)
- Catherine E. Bowen (ORCID: https://orcid.org/0000-0003-3887-2691)
- Dana Kristjansson (ORCID: https://orcid.org/0000-0003-0687-2910)
- Bernt Bratsberg (ORCID: https://orcid.org/0000-0002-6874-3412)
- Astanand Jugessur (ORCID: https://orcid.org/0000-0003-1365-8322)
- Ekaterina Zotcheva (ORCID: https://orcid.org/0000-0002-5777-4731)
- Sarah E. Tom (ORCID: https://orcid.org/0000-0003-0094-5138)
- Steinar Krokstad (ORCID: https://orcid.org/0000-0002-2932-6675)
- Yaakov Stern (ORCID: https://orcid.org/0000-0001-7542-3241)
- Katrin Wolfová (ORCID: https://orcid.org/0000-0003-0295-8848)
- Bo Engdahl (ORCID: https://orcid.org/0000-0002-9166-5782)
- Hans‐Peter Kohler (ORCID: https://orcid.org/0000-0003-0639-4349)
- Asta Kristine Haberg (ORCID: https://orcid.org/0000-0002-9007-1202)
- Vegard Skirbekk (ORCID: https://orcid.org/0000-0002-1647-3246)
- Jennifer R. Harris (ORCID: https://orcid.org/0000-0003-3249-8918)
- Trine Holt Edwin (ORCID: https://orcid.org/0000-0002-0530-8771)
- Teferi Mekonnen (ORCID: https://orcid.org/0000-0002-3319-9138)
- Bjørn Heine Strand (ORCID: https://orcid.org/0000-0003-4385-8886)
- Yehani Wedatilake (ORCID: https://orcid.org/0000-0002-9268-7385)
Institutions
- Oslo University Hospital (NO)
- Norwegian Institute of Public Health (NO)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Charles University (CZ)
- Levanger Hospital (NO)
- Sykehuset i Vestfold (NO)
- University of Bergen (NO)
- Columbia University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1186/s12883-025-04044-4
- Citations
- 2
- Primary Topic
- Health disparities and outcomes
- Type
- article
- Field-Weighted Citation Impact
- 4.33
Funders
- Norges Teknisk-Naturvitenskapelige Universitet
- Norges Forskningsråd
- National Institutes of Health
- Faculty of Medicine and Health, University of Sydney
- Norwegian Institute of Public Health