FOXP3, IL-35, and PD-L1 in intra- and peritumoral lymphocytic infiltrate of cutaneous melanomas as an important part of antitumor immunity
This article demonstrates that the immunosuppressive environment develops in proportion to the stage of the melanoma. The most significant changes are found at the tumor periphery, confirming the heterogeneity of the tumor stroma which is more pronounced in more advanced tumors and which may contribute to the greater aggressiveness in these peripheral zones.
Authors
- Jiří Ehrmann (ORCID: https://orcid.org/0000-0002-8419-3414)
- Yvetta Vantuchová (ORCID: https://orcid.org/0000-0001-8022-7683)
- Pavel Hurník (ORCID: https://orcid.org/0000-0001-9913-7039)
- Simona Michalčová (ORCID: https://orcid.org/0009-0000-6961-9141)
- Jozef Škarda (ORCID: https://orcid.org/0000-0003-3579-3066)
- Dana Purová
- Vladimír Židlík (ORCID: https://orcid.org/0000-0002-3179-9252)
- Tereza Hulinova
Institutions
- University of Ostrava (CZ)
- University Hospital Ostrava (CZ)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Biomedical Papers
- Published
- 2025-01-27
- DOI
- https://doi.org/10.5507/bp.2024.040
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00