The methyl-CpG binding domain 2 regulates peptidylarginine deiminase 4 expression and promotes neutrophil extracellular trap formation via the Janus kinase 2 signaling pathway in experimental severe asthma
MBD2 regulates PAD4 expression through the JAK2 signaling pathway to promote NETs formation in mice with severe asthma. Further bench-based and bedside-based studies targeting the MBD2, PAD4, and JAK2 signaling pathways will help open new avenues for drug development of severe asthma.
Authors
- Da Liu (ORCID: https://orcid.org/0000-0002-5113-4004)
- Biao Peng (ORCID: https://orcid.org/0000-0002-7297-2883)
- Mu-Yun Yan
- Yun-Rong Chen
- Fei Sun (ORCID: https://orcid.org/0000-0001-8184-6718)
- Xu-Dong Xiang (ORCID: https://orcid.org/0000-0001-5754-3346)
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- Changsha Central Hospital (CN)
- Hunan Provincial People's Hospital (CN)
- Second Xiangya Hospital of Central South University (CN)
- Tongji Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-01-27
- DOI
- https://doi.org/10.1080/07853890.2025.2458207
- Citations
- 2
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- National Natural Science Foundation of China