EFFECT OF SYSTEMIC IMMUNE-INFLAMMATION INDEX ON MORTALITY IN PATIENTS WITH PERIPHERAL ARTERY DISEASE

OBJECTIVE: Peripheral artery disease ranks as the third leading cause of death and illness following coronary artery disease and cerebrovascular disease among atherosclerotic conditions, representing a significant health concern worldwide. Our study aims to explore the association between the systemic immune- inflammation index a combined marker of inflammation and aggregation and survival in patients with peripheral artery disease. MATERIAL AND METHODS: In this retrospective cohort study, we examined the medical records of 432 individuals diagnosed with peripheral artery disease between the years 2010 and 2020. The systemic immune-inflammation index was calculated based on platelet to lymphocyte ratios from the patients’ complete blood count tests, and the relationship between this index and mortality was assessed using the Kaplan-Meier survival analysis. RESULTS: Our findings demonstrate that the systemic immune- inflammation index is an independent predictor of mortality in peripheral artery disease. Statistical analyses have shown that higher values of the systemic immune-inflammation index (> 854), correlate with increased mortality in individuals with peripheral artery disease and type two diabetes mellitus (OR: 1.02, %95 GA: 0.98-1.04, p<0.001). CONCLUSIONS: In conclusion, the systemic immune-inflammation index is a significant determinant of survival in patients with peripheral artery disease. These results can enhance our understanding of the role of inflammation and immune response in the management of peripheral artery disease and may contribute to developing potential therapeutic strategies.