Investigation of the Antibacterial Activity and Antiproliferative Properties of Ag Nanoparticles Synthesized Using Lavandula angustifolia Sevtopolis Extract against Prostate Cancer Cell Lines

Introduction: In this study, silver nanoparticles (AgNPs) were synthesized using Lavandula angustifolia Sevtopolis (LA Sevtapolis) plant extract without using any reducing or stabilizing agent. Methods: The morphologies, optical properties, and crystallinities of the prepared AgNPs were determined using scanning electron microscopy, UV-visible spectroscopy, and X-ray diffraction. Results: The antibacterial activities of the synthesized AgNPs against some gram-negative and gram-positive bacterial species were investigated. The lowest effect was observed against the Gram-positive B. cereus ATCC 11778 with a concentration of 0.0375 μg/mL. Additionally, the toxic effect on the human normal cell line HEK-293T and the antiproliferative activity against the prostate (PC3) cancer cell line were examined. The IC50 values of AgNPs against PC3 and HEK- 293T cells were found to be 4.72 μL/mL and 6.838 μL/mL, respectively. Conclusion: In conclusion, due to their antiproliferative and antibacterial activities, AgNPs synthesized using LA Sevtopolis extract were found to have potential applications in various biomedical fields.