Lafora Disease in Two Beagle Dogs—Clinical and Anatomopathological Case Report

Abstract Lafora disease consists of the accumulation of polyglucosan bodies in the brain, usually causing neurodegenerative epilepsy. Two dogs, aged 13 (case 1) and 19 (case 2) respectively, of the beagle breed, presented clinical neurological signs such as convulsions, walking in circles, and decreased proprioception. The first animal died after a seizure, which progressed to cardiorespiratory arrest and death, while the second animal was euthanized, and both were referred for necropsy. Histopathological analysis of the brain revealed the presence of numerous Lafora bodies distributed in the gray matter of the entire brain (case 1) and in the cerebellum in case 2. After histochemical analysis (Periodic Acid-Schiff) and correlation with the clinical signs, Lafora disease was diagnosed in both animals. Cite this article as: Morais R. A. L., Rodrigues, A., Santos, M. V. P., Mioto, B. C., Mizobe, A. C., Molinaro, E. C., Theodoro, S. S., Braz, J. B., Carciofi, A. C., & Vasconcelos, R. O. (2025). Lafora disease in two beagle dogs—clinical and anatomopathological case report. Acta Veterinaria Eurasia, 51, 0057, doi: 10.5152/actavet.2025.24057.