Untargeted Metabolomics and Bioactivities Assessment of Xylaria ellisii, an Endophytic Fungus Isolated from the Leaf of the Plant Acorus calamus Linn.
The top-scoring Keap1 inhibitors derived from <i>Xylaria ellisii</i>, including Pregabalin (-6.083 Kcal/mol), Ferulic acid (-5.434 Kcal/mol), (R)-Piperidine-2-carboxylic acid (-5.31 Kcal/mol), Genipin (-5.197 Kcal/mol), and Brivaracetam (-5.17 Kcal/mol), respectively were considered as Keap 1 inhibitors, potentially mitigate oxidative stress.
Authors
- Naina Rajak (ORCID: https://orcid.org/0009-0009-0653-3071)
- Santosh Kumar Singh (ORCID: https://orcid.org/0000-0003-0575-9019)
- Neha Garg (ORCID: https://orcid.org/0000-0003-2227-8292)
- Sachchida Nand (ORCID: https://orcid.org/0000-0001-8418-9549)
- Santosh Kumar Singh (ORCID: https://orcid.org/0000-0001-6521-7719)
- Chandrabhan Prajapati (ORCID: https://orcid.org/0000-0003-0589-0578)
Institutions
- Institute of Medical Sciences (IN)
- Indian Institute of Technology BHU (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-01-27
- DOI
- https://doi.org/10.2174/0113816128337697250106001808
- Citations
- 10
- Primary Topic
- Medicinal Plants and Neuroprotection
- Type
- article
- Field-Weighted Citation Impact
- 23.81